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产品目录

Securin/PTTG1抗体图片
产品货号:
Z33972
中文名称:
Securin/PTTG1抗体
英文名称:
Anti-Securin/PTTG1 Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-Securin/PTTG1 Antibody
指标别名EAP1;Esp1 associated protein;HPTTG;pituitary tumor transforming 1;PTTG;PTTG1;Securin;Tumor transforming protein 1;TUTR1
克隆性Monoclonal
检验物种human
应用范围WB
基因名称PTTG1
抗体来源Rabbit
抗体类型IgG
免疫原A synthesized peptide derived from human Securin Regulatory protein,which plays a central role in chromosome stability,in the p53/TP53 pathway,and DNA repair.Probably acts by blocking the action of key proteins.During the mitosis,it blocks Separase/ESPL1 function,preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes.
实际分子量22KD/28KD
成分500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol.
纯化方式Affinity-chromatography
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料Securin,also known as pituitary tumor-transforming 1 or EAP1 is a protein that in humans is encoded by the PTTG1 gene.PTTG1 gene is mapped to 5q33.3.The encoded protein is a homolog of yeast securin proteins,which prevent separins from promoting sister chromatid separation.It is an anaphase-promoting complex(APC) substrate that associates with a separin until activation of the APC.The gene product has transforming activity in vitro and tumorigenic activity in vivo,and the gene is highly expressed in various tumors.The gene product contains 2 PXXP motifs,which are required for its transforming and tumorigenic activities,as well as for its stimulation of basic fibroblast growth factor expression.It also contains a destruction box(D box) that is required for its degradation by the APC.The acidic C-terminal region of the encoded protein can act as a transactivation domain.The gene product is mainly a cytosolic protein,although it partially localizes in the nucleus.
Uniprot IDO95997
推荐稀释比
Western blot (WB) 1:500~2000

相关搜索:Securin/PTTG1抗体Securin抗体PTTG1单抗Anti-Securin/PTTG1 Antibody
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