产品货号：
Z33972
中文名称：
Securin/PTTG1抗体
英文名称：
Anti-Securin/PTTG1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Securin/PTTG1 Antibody |
| 指标别名 | EAP1;Esp1 associated protein;HPTTG;pituitary tumor transforming 1;PTTG;PTTG1;Securin;Tumor transforming protein 1;TUTR1 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | PTTG1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human Securin Regulatory protein,which plays a central role in chromosome stability,in the p53/TP53 pathway,and DNA repair.Probably acts by blocking the action of key proteins.During the mitosis,it blocks Separase/ESPL1 function,preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. |
| 实际分子量 | 22KD/28KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Securin,also known as pituitary tumor-transforming 1 or EAP1 is a protein that in humans is encoded by the PTTG1 gene.PTTG1 gene is mapped to 5q33.3.The encoded protein is a homolog of yeast securin proteins,which prevent separins from promoting sister chromatid separation.It is an anaphase-promoting complex(APC) substrate that associates with a separin until activation of the APC.The gene product has transforming activity in vitro and tumorigenic activity in vivo,and the gene is highly expressed in various tumors.The gene product contains 2 PXXP motifs,which are required for its transforming and tumorigenic activities,as well as for its stimulation of basic fibroblast growth factor expression.It also contains a destruction box(D box) that is required for its degradation by the APC.The acidic C-terminal region of the encoded protein can act as a transactivation domain.The gene product is mainly a cytosolic protein,although it partially localizes in the nucleus. |
| Uniprot ID | O95997 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
相关搜索：Securin/PTTG1抗体，Securin抗体，PTTG1单抗，Anti-Securin/PTTG1 Antibody